2024

• Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression

Lee NY, Choi MG, Lee EJ, Koo JH

Archives of Pharmacal Research, 2024; 47(6):558-570.

• • Featured on the journal cover

• Endoplasmic Reticulum Stress Activates Hepatic Macrophages through PERK-hnRNPA1 Signaling

Kwon A, Kim YS, Kim J, Koo JH

Biomolecules & Therapeutics, 2024; 32(3):341-348.

• Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Kwon A, Lee NY, Yu JH, Choi MG, Park J, Koo JH

Cell Death & Disease, 2024; 15(1):51.

• Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation

Yu JH, Choi MG, Lee NY, Kwon A, Lee E, Koo JH

Cell Commununication and Signaling, 2024; 22(1):48.

2022

• Nuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival

Lee JM, Lee JW, Thuy PX, Koo JH, Moon EY.

Scientific Reports, 2022; 12(1):20170.

• NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury

Kim A*, Koo JH*, Lee JM, Joo MS, Kim TH, Jang K, Jun DW, Kim SG. (*equally contributed)

FASEB Journal, 2022; 36(3):e22170.

2020

• Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth.

Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL.

Genes & Development, 2020; 34:72-86.

2018

• Interplay between YAP/TAZ and metabolism

Koo JH, Guan KL.

Cell Metabolism, 2018;28(2):196-206.

• Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration

Kim TH*, Yang YM*, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. (*equally contributed)

Journal of Clinical Investigation, 2018; 128(12):5587-602.

• Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells

Kim KM, Han CY, Kim JY, Cho SS, Kim YS, Koo JH, Lee JM, Lim SC, Kang KW, Kim JS, Hwang SJ, Ki SH, Kim SG.

Journal of Hepatology, 2018; 68(3):493-504.

• Gα12 regulates osteoclastogenesis by modulating NFATc1 expression

Song MK, Park C, Lee YD, Kim H, Kim MK, Kwon JO, Koo JH, Joo MS, Kim SG, Kim HH.

Journal of Cellular and MolecularMedicine, 2018; 22(2):849-60.

2016

• Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Han CY, Koo JH, Kim SH, Gardenghi S, Rivella S, Strnad P, Hwang SJ, Kim SG.

Nature Communications, 2016; 22(7):13817.

• Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function

Han CY*, Kim TH*, Koo JH, Kim SG. (*equally contributed)

Archives of Pharmacal Research, 2016; 39(8):1062-74.

• PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury

Han CY, Lim SW, Koo JH, Kim W, Kim SG.

Gut, 2016; 65(8):1377-88.

• AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550

Joo MS*, Kim WD*, Lee KY, Kim JH, Koo JH, Kim SG. (*equally contributed)

Molecular and Cellular Biology, 2016; 36(14):1931-42.

• • • Featured on the “Spotlight” section

• Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and upregulation of SMAD2

Koo JH, Lee HJ, Kim W, Kim SG.

Gastroenterology, 2016; 150(1):181-93.

2014

• microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression

Heo MJ, Kim YM, Koo JH, Yang YM, An J, Lee SK, Lee SJ, Kim KM, Park JW, Kim SG.

Oncotarget, 2014; 5(9):2792-806.

• Gα12 gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation

Jung HS*, Seo YR*, Yang YM, Koo JH, An J, Lee SJ, Kim KM, Kim SG. (*equally contributed)

Cellular Signalling, 2014; 26(7):1456-65.

2012

• Fyn Inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury

Koo JH, Lee WH, Lee CG, Kim SG.

Molecular Pharmacology, 2012; 82:27-36.