연구 성과 (논문 및 특허)
연구 성과 (논문 및 특허)
모든 연구 성과는 SCI(E) 등재 국제 학술지에 게재됩니다.
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2025
2025
Stabilizing Hepatic Fatty Acid Oxidation: USP29 Secures Acyl-CoA Synthesis through ACSL5
Choi MG, Lee NY, Koo JH
Clinical and Molecular Hepatology, 2025; 31:592-595.
2024
2024
Longitudinal evaluation of liver stiffness reveals hepatic cholesterol as the determinant of fibrosis progression in mice
Lee NY, Koo JH
Life Sciences, 2024; 358:123201.
Interplay between YAP/TAZ and metabolic dysfunction-associated steatotic liver disease progression
Lee NY, Choi MG, Lee E, Koo JH
Archives of Pharmacal Research, 2024; 47(6):558-570.
Featured on the journal cover
Endoplasmic Reticulum Stress Activates Hepatic Macrophages through PERK-hnRNPA1 Signaling
Kwon A, Kim YS, Kim J, Koo JH
Biomolecules & Therapeutics, 2024; 32(3):341-348.
Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
Kwon A, Lee NY, Yu JH, Choi MG, Park J, Koo JH
Cell Death & Disease, 2024; 15(1):51.
Hepatocyte GPCR signaling regulates IRF3 to control hepatic stellate cell transdifferentiation
Yu JH, Choi MG, Lee NY, Kwon A, Lee E, Koo JH
Cell Communication and Signaling, 2024; 22(1):48.
2023
2023
Identification of the primary ciliary proteins IFT38 and IFT144 to enhance serum-mediated YAP activation and cell proliferation
Yu JH, Kim JH, Soung NK, Moon EY, Koo JH.
Biochemical and Biophysical Research Communications, 2023; 681:186-193.
ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
Jeong H, Hong EH, Ahn JH, Cho J, Jeong JH, Kim CW, Yoon BI, Koo JH, Park YY, Yang YM, Iwawaki T, Vallance BA, Chang SY, Ko HJ.
Experimental and Molecular Medicine, 2023; 55(2):401-412.
Identification of Small GTPases That Phosphorylate IRF3 through TBK1 Activation Using an Active Mutant Library Screen
Yu JH, Moon EY, Kim J, Koo JH.
Biomolecules & Therapeutics, 2023; 31(1):48-58.
2022
2022
Nuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival
Lee JM, Lee JW, Thuy PX, Koo JH, Moon EY.
Scientific Reports, 2022; 12(1):20170.
NRF2-mediated SIRT3 induction protects hepatocytes from ER stress-induced liver injury
Kim A*, Koo JH*, Lee JM, Joo MS, Kim TH, Jang K, Jun DW, Kim SG. (*equally contributed)
FASEB Journal, 2022; 36(3):e22170.
2021
2021
Ablation of USP21 in skeletal muscle promotes oxidative fibre phenotype, inhibiting obesity and type 2 diabetes
Kim A, Koo JH, Jin X, Kim W, Park SY, Park S, Rhee EP, Choi CS, Kim SG.
Journal of Cachexia Sarcopenia and Muscle, 2021; 12(6):1669-1689.
Signaling nodes associated with endoplasmic reticulum stress during NAFLD progression
Koo JH*, Han CY* (*co-correspondence)
Biomolecules, 2021; 11(2):242.
ROCK2를 표적으로 하는 산화대사형 근섬유 비율 증가제 스크리닝 방법
김상건, 구자현
대한민국 특허, 10-2201200 (등록), 2021.01.15.
2020
2020
Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth.
Koo JH, Plouffe SW, Meng Z, Lee DH, Yang D, Lim DS, Wang CY, Guan KL.
Genes & Development, 2020; 34:72-86.
2019
2019
비만 및 당뇨 개선을 위한 골격근 대사 활성화제로서의 ROCK2 억제제
김상건, 구자현, 최철수
대한민국 특허, 10-2019-0116920 (등록) / 국제출원(PCT), WO 1019/194598 A1
Overproduction of inter-α-trypsin inhibitor heavy chain 1 after loss of Gα13 in liver exacerbates systemic insulin resistance in mice
Kim TH, Koo JH, Heo MJ, Han CY, Kim YI, Park SY, Cho IJ, Lee CH, Choi CS, Lee JW, Kim W, Cho JY, Kim SG.
Science Translational Medicine, 2019; 11(513):eaan4735.
Liver X receptor α-induced cannabinoid receptor 2 inhibits ubiquitin-specific peptidase 4 through miR-27b, protecting hepatocytes from TGF-β
Wu HM, Kim TH, Kim AY, Koo JH, Joo MS, Kim SG.
Hepatology Communications, 2019; 3(10):1373-87.
Nrf2-lncRNA controls cell fate by modulating p53-dependent Nrf2 activation as a miRNA sponge for Plk2 and p21cip1
Joo, MS, Shin SB, Kim EJ, Koo JH, Yim H, Kim SG.
FASEB Journal, 2019; 33(7):7953-969.
Cell type-dependent function of LATS1/2 in cancer cell growth
Pan WW, Moroishi T, Koo JH, Guan KL.
Oncogene, 2019; 38(14):2595-610.
LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis
Joo MS*, Koo JH*, Kim TH, Kim YS, Kim SG. (*equally contributed)
EBioMedicine, 2019; 40:488-503.
2018
2018
Interplay between YAP/TAZ and metabolism
Koo JH, Guan KL.
Cell Metabolism, 2018;28(2):196-206.
Gα12 ablation exacerbates liver steatosis and obesity by suppressing USP22/SIRT1-regulated mitochondrial respiration
Kim TH*, Yang YM*, Han CY, Koo JH, Oh H, Kim SS, You BH, Choi YH, Park TS, Lee CH, Kurose H, Noureddin M, Seki E, Wan YY, Choi CS, Kim SG. (*equally contributed)
Journal of Clinical Investigation, 2018; 128(12):5587-602.
Gα12 overexpression induced by miR-16 dysregulation contributes to liver fibrosis by promoting autophagy in hepatic stellate cells
Kim KM, Han CY, Kim JY, Cho SS, Kim YS, Koo JH, Lee JM, Lim SC, Kang KW, Kim JS, Hwang SJ, Ki SH, Kim SG.
Journal of Hepatology, 2018; 68(3):493-504.
Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
Song MK, Park C, Lee YD, Kim H, Kim MK, Kwon JO, Koo JH, Joo MS, Kim SG, Kim HH.
Journal of Cellular and Molecular Medicine, 2018; 22(2):849-60.
2017
2017
Gα13 ablation reprograms myofibers to oxidative phenotype and enhances whole-body metabolism
Koo JH, Kim TH, Park SY, Joo MS, Han CY, Choi CS, Kim SG.
Journal of Clinical Investigation, 2017; 127(10):3845-60.
Highlighted on the “JCI This Month Editor’s Picks”
Oligopeptide competition assay for phosphorylation site determination
Joo MS, Koo JH, Shin SB, Yim H, Kim SG.
Journal of Visualized Experiments, 2017; 123:e55708.
2016
2016
Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt
Han CY, Koo JH, Kim SH, Gardenghi S, Rivella S, Strnad P, Hwang SJ, Kim SG.
Nature Communications, 2016; 22(7):13817.
Farnesoid X receptor as a regulator of fuel consumption and mitochondrial function
Han CY*, Kim TH*, Koo JH, Kim SG. (*equally contributed)
Archives of Pharmacal Research, 2016; 39(8):1062-74.
PHLDA3 overexpression in hepatocytes by endoplasmic reticulum stress via IRE1-Xbp1s pathway expedites liver injury
Han CY, Lim SW, Koo JH, Kim W, Kim SG.
Gut, 2016; 65(8):1377-88.
AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550
Joo MS*, Kim WD*, Lee KY, Kim JH, Koo JH, Kim SG. (*equally contributed)
Molecular and Cellular Biology, 2016; 36(14):1931-42.
Featured on the “Spotlight” section
Endoplasmic reticulum stress in hepatic stellate cells promotes liver fibrosis via PERK-mediated degradation of HNRNPA1 and upregulation of SMAD2
Koo JH, Lee HJ, Kim W, Kim SG.
Gastroenterology, 2016; 150(1):181-93.
2015
2015
Phytochemical regulation of Fyn and AMPK signaling circuitry
Lee CG*, Koo JH*, Kim SG. (*equally contributed)
Archives of Pharmacal Research, 2015; 38(12):2093-105.
Featured on the journal cover
Gα12 overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction
Yang YM, Lee CG, Koo JH, Kim TH, Lee JM, An J, Kim KM, Kim SG.
Oncotarget, 2015; 6(22):19055-69.
2014
2014
microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression
Heo MJ, Kim YM, Koo JH, Yang YM, An J, Lee SK, Lee SJ, Kim KM, Park JW, Kim SG.
Oncotarget, 2014; 5(9):2792-806.
Gα12 gep oncogene inhibits FOXO1 in hepatocellular carcinoma as a consequence of miR-135b and miR-194 dysregulation
Jung HS*, Seo YR*, Yang YM, Koo JH, An J, Lee SJ, Kim KM, Kim SG. (*equally contributed)
Cellular Signalling, 2014; 26(7):1456-65.
2013
2013
miR-125b transcriptionally increased by Nrf2 inhibits AhR repressor, which protects kidney from cisplatin-induced injury
Joo MS, Lee CG, Koo JH, Kim SG.
Cell Death & Disease, 2013; 4:e899.
2012
2012
Fyn Inhibition by cycloalkane-fused 1,2-dithiole-3-thiones enhances antioxidant capacity and protects mitochondria from oxidative injury
Koo JH, Lee WH, Lee CG, Kim SG.
Molecular Pharmacology, 2012; 82:27-36.
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